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field testing can also be helpful in the diagnosis
                                                              of NAION. NAION often presents with an inferior
                                                              altitudinal, inferior nasal, or cecocentral visual
                                                              field defect (Figure 4).  In rare cases, the visual
                                                                                    4
                                                              field defect may present as a pure central
                                                              defect.  Surprisingly, colour vision is typically
                                                                     6
                                                              unaffected due to relatively untouched macular
                                                              fibers of the nerve in this condition. 6

                                                              MANAGEMENT
                                                                 Unilateral disc edema may also be a sign
                                                              of a variety of other disorders including optic
                                                              disc drusen, asymmetric papilledema, optic
                                                              neuritis, and arteritic anterior ischemic optic
                                                              neuropathy (AAION).  Optic disc drusen is
                                                                                   5
          FIGURE 1 - OPTIC DISC EDEMA WITH INDISTINCT DISC    typically bilateral and shows calcific deposits
          MARGINS SECONDARY TO NAION                          that are hyperfluorescent with autofluorescence
                                                              imaging. Papilledema is always bilateral but
                                                              can present asymmetrically and is associated
                                                              with an increase in intracranial pressure. Optic
                                                              neuritis often presents in females in their 30’s,
                                                              may exhibit dyschromatopsia in the affected eye,
                                                              and is associated with painful eye movements.
                                                                                                            7
                                                              The most common etiology of optic neuritis is
                                                              multiple sclerosis. 7

                                                                 The most notable differential is AAION, which
                                                              must be excluded due to its association with
                                                              giant cell arteritis (GCA) which has a significant
                                                              potential to cause severe and permanent vision
                                                              loss in both eyes. The clinical presentation
                                                              of AAION is similar to that of NAION but is
                                                                                                 2
          FIGURE 2 - A “DISC AT RISK” MARKED BY               marked by a number of “red flags”.  These
          A CROWDED OPTIC NERVE HEAD WITH A                   “red flags” include new onset headache,
          SMALL CUP-TO-DISC RATIO (<0.3)                      jaw claudication (ischemia of the masseter
                                                              muscles) and scalp tenderness, especially
          often referred to as a “disc at risk” (Figure 2).    around the temporal forehead. Testing for
                                                      4,5
          The combination of an edematous disc in the         AAION includes an erythrocyte sedimentation
          affected eye and the fellow eye which exhibits      rate, C-reactive protein, complete blood count
          a “disc at risk”, provide a strong case for the     to check for anemia, platelets, and a temporal
          diagnosis of NAION.

             Additional testing can also be beneficial         NON-ARTERITIC ANTERIOR ISCHEMIC
          in the diagnosis of NAION. Optical coherence         OPTIC NEUROPATHY (NAION) IS
          tomography (OCT) is a useful tool not only           THE MOST COMMON ACUTE OPTIC
          in detecting the presence of the optic nerve         NEUROPATHY IN PATIENTS OVER
          edema but determining if the fellow eye has a
          “disc at risk” (Figure 3). OCT imaging can offer     THE AGE OF 50 AND IS THE PRIMARY
          a quantitative analysis both of the amount of        CAUSE OF OPTIC NERVE-RELATED
          edema of the affected eye, as well as the size       ACUTE VISION LOSS
          and cup-to-disc ratio of the fellow eye. Visual


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