Page 86 - The Indian Optician Digital Edition May-Junel 2022

corneal transplants may also fail. damaged the cornea, the poorer the outcome.
As he sheds light on the fact of the matter, “The
This is why the respective team used success of a corneal transplant depends upon
nanoparticles and sub-microscopic particles the health of the cornea before the operation.”
to develop a gelatin-based eye drop system
that could deliver effective and long-lasting Dr Liu says the new drop would be more
treatment to the corneal surface. These effective and long-lasting than traditional eye
nanoparticle eye drops could prove to be drops, as nanoparticle formulation is used in
more effective at preventing vision loss than this case, thus making them ‘stickier’ than
traditional eye drops. These drops could usual. He further adds, “You constantly need to
potentially replace eye injections and, in some use eye drops, three or four times a day, even
cases, help to avoid invasive surgery by using more frequently, to stop the deterioration of the
the eye drop system to transport drugs to treat cornea. We enabled a nanoparticle to carry a
retinal conditions internally. The nanoparticle drug as an eye drop so that the particle can stick
can help drugs reach deep into the retinal tissue to the cornea and then slowly release the drug,
from the eye surface. As Dr Liu reassures, “This is thus resulting in better treatment outcomes for
a simple but effective way to get our medicines corneal disease. We demonstrated that with just
where we want them to go without probing or one drop a day you can minimise this severe
poking around the eye.” corneal deterioration.”
Professor Liu further shares that corneal The new step for the team includes
transplant outcomes could also be improved optimising the eye drop formulation in pre-
by halting more tissue damage and preventing clinical studies, hopefully shortly; and testing
excessive blood vessel growth in the lead-up to the treatment via clinical trials, potentially in
surgery. Following a transplant, the new cornea the long term. This initiative can modify the
is attached to the existing tissue and must formulation to treat retinal disease and help
fit well. Associate Professor Liu says the more many more patients in need.

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